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Article

Aberrant Hypermethylation of Tumor Suppressor Genes in Pancreatic Endocrine Neoplasms

1 Sept 2003

Abstract excerpt

OBJECTIVE: Because histologic features can be unreliable in determining the malignant potential of pancreatic endocrine neoplasms (PENs), we characterized the methylation patterns of PENs to develop a molecular marker system useful for clinical prognosis. SUMMARY BACKGROUND DATA: Aberrant promoter methylation of tumor suppressor genes is associated with a loss of gene function that can afford selective growth...

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Share to Epigenetics and DNA Methylation
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PMID: 14501508
DOI: 10.1097/01.sla.0000086659.49569.9e

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