Article
Predisposition towards urolithiasis associated with the NQO1 null-allele.
Pharmacogenetics - 1 Oct 1998
Schulz W A, Krummeck A, Rösinger I, Schmitz-Dräger B J, Sies H
Abstract excerpt
The distribution of two alleles of the NQO1 gene encoding NADP(H):quinone oxidoreductase was studied in 140 urolithiasis patients and 271 control individuals. The minor allele encoding a protein lacking quinone reductase activity was significantly more frequent (q = 0.214) among these patients than in control individuals (P = 0.135) indicating an increased risk for kidney stone formation among heterozygotes (odds...
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