Predisposition towards urolithiasis associated with the NQO1 null-allele.

doi:10.1097/00008571-199810000-00011

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Article

Predisposition towards urolithiasis associated with the NQO1 null-allele.

Pharmacogenetics - 1 Oct 1998

Schulz W A, Krummeck A, Rösinger I, Schmitz-Dräger B J, Sies H

Abstract excerpt

The distribution of two alleles of the NQO1 gene encoding NADP(H):quinone oxidoreductase was studied in 140 urolithiasis patients and 271 control individuals. The minor allele encoding a protein lacking quinone reductase activity was significantly more frequent (q = 0.214) among these patients th...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Calcium-Binding Proteins
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Middle Aged
NAD(P)H Dehydrogenase (Quinone)
Protein Processing, Post-Translational
Urinary Calculi

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