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Article

Loss of heterozygosity and DNA methylation affect germline fibroblast growth factor receptor 4 polymorphism to direct allelic selection in breast cancer.

The American journal of pathology - 1 Dec 2010

Zhu Xuegong, Zheng Lei, Asa Sylvia L, Ezzat Shereen

Abstract excerpt

Genome-wide association studies highlight the importance of the fibroblast growth factor (FGF) receptor as a risk factor for breast cancer development. In particular, FGFR4 has been implicated in membrane ruffling, cancer cell invasiveness, and clinical chemoresistance in breast cancer. In this work, we studied FGFR4 in both human breast cancers and cell lines. We examined primary human microdissected breast...

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Source

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Identifiers

PMID: 21037081
DOI: 10.2353/ajpath.2010.100509
PMCID: PMC2993303

Genes

FGFR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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