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Article

Regeneration-blocked mdx muscle: in vivo model for testing treatments.

Muscle & nerve - 1 Aug 1997

Quinlan J G, Cambier D, Lyden S, Dalvi A, Upputuri R K, Gartside P, Michaels S E, Denman D

Abstract excerpt

We have refined the mdx mouse as a clinical model for Duchenne dystrophy. Our power estimates, primary measures, regular sacrifice intervals, and quality checks constitute a high-speed, low-cost system for preclinically testing therapies designed to slow muscle destruction in Duchenne dystrophy. Irradiated (18 Gy) and contralateral shielded anterior tibial muscles were studied in 21-day-old mdx and normal mice at...

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Source

Identifiers

PMID: 9236793
DOI: 10.1002/(sici)1097-4598(199708)20:8<1016::aid-mus12>3.0.co;2-t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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