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Article

Radiation induces long-term muscle fibrosis and promotes a fibrotic phenotype in fibro-adipogenic progenitors.

Journal of cachexia, sarcopenia and muscle - 1 Oct 2023

Collao Nicolas, D'Souza Donna, Messeiller Laura, Pilon Evan, Lloyd Jessica, Larkin Jillian, Ngu Matthew, Cuillerier Alexanne, Green Alexander E, Menzies Keir J, Burelle Yan, De Lisio Michael

Abstract excerpt

BACKGROUND: Radiation-induced muscle pathology, characterized by muscle atrophy and fibrotic tissue accumulation, is the most common debilitating late effect of therapeutic radiation exposure particularly in juvenile cancer survivors. In healthy muscle, fibro/adipogenic progenitors (FAPs) are required for muscle maintenance and regeneration, while in muscle pathology FAPs are precursors for exacerbated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37671686
DOI: 10.1002/jcsm.13320
PMCID: PMC10570115

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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