Enhanced skeletal muscle fatigue tolerance through cell transplantation-mediated dystrophin supplementation in a mouse model of Duchenne Muscular Dystrophy

Abstract excerpt

<title>Abstract</title> <p>Background Duchenne muscular dystrophy (DMD) is an incurable neuromuscular disease leading to progressive skeletal muscle weakness and fatigue. Cell transplantation in murine models have shown promise in supplementing the lack of the dystrophin protein in DMD muscles. However, the establishment of novel, long-term, relevant methods is needed to assess its efficiency on the DMD motor fu...

Topics

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• Disease Models, Animal
• Dystrophin
• Genetic Therapy
• Models, Biological
• Muscular Dystrophies
• Muscular Dystrophy, Duchenne
• Mutation
• Utrophin

Identifiers and source

Literature Corpus work

4144d040-2c05-59a4-b15b-e23bb8a08050

DOI

10.21203/rs.3.rs-3767279/v1