Major alteration of the pathological phenotype in gamma irradiated mdx soleus muscles.

Abstract excerpt

Two thousand rads of gamma irradiation delivered to the lower legs of ten day old normal and x-chromosome linked muscular dystrophy (mdx) mice caused significant inhibition of tibial bone and soleus muscle fiber growth. In the irradiated mdx solei, there was a major loss of muscle fibers, lack of central nucleation, and some endomysial fibrosis. These features were caused by a failure of regeneration of muscle...

Topics

• Animals
• Bone Development
• Mice
• Mice, Inbred C57BL
• Muscle Development
• Muscles
• Muscular Dystrophy, Animal
• Phenotype