Molecular tuning of an EF-hand-like calcium binding loop. Contributions of the coordinating side chain at loop position 3.

doi:10.1085/jgp.110.2.173

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Article

Molecular tuning of an EF-hand-like calcium binding loop. Contributions of the coordinating side chain at loop position 3.

The Journal of general physiology - 1 Aug 1997

Drake S K, Zimmer M A, Kundrot C, Falke J J

Abstract excerpt

Calcium binding and signaling orchestrate a wide variety of essential cellular functions, many of which employ the EF-hand Ca2+ binding motif. The ion binding parameters of this motif are controlled, in part, by the structure of its Ca2+ binding loop, termed the EF-loop. The EF-loops of different...

Topics

Calcium-Binding Proteins
Kinetics
Metals
Models, Molecular
Monosaccharide Transport Proteins
Mutation
Periplasmic Binding Proteins
Protein Engineering
Signal Transduction

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