Article

Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function

2021-10-06

Abstract excerpt

Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system (CNS). Excitatory Amino Acid Transporters (EAATs) regulate extracellular glutamate by transporting it into cells, mostly glia, to terminate neurotransmission and to avoid neurotoxicity. EAATs are also chloride (Cl − ) channels, but the physiological role of Cl − conductance through EAATs is poorly understood. Mutatio...

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Literature Corpus work: 0a96bbdd-e2fc-5f5f-93c3-1b3ce16ed725
DOI: 10.1101/2021.10.05.463128

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