Article
The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters.
Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009
Teichman Shlomit, Qu Shaogang, Kanner Baruch I
Abstract excerpt
Glutamate transporters maintain low synaptic concentrations of neurotransmitter by coupling uptake to flux of other ions. Their transport cycle consists of two separate translocation steps, namely cotransport of glutamic acid with three Na(+) followed by countertransport of K(+). Two Tl(+) binding sites, presumed to serve as sodium sites, were observed in the crystal structure of a related archeal homolog and the...
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