Article
Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function.
The Journal of clinical investigation - 1 Apr 2022
Wu Qianyi, Akhter Azman, Pant Shashank, Cho Eunjoo, Zhu Jin Xin, Garner Alastair, Ohyama Tomoko, Tajkhorshid Emad, van Meyel Donald J, Ryan Renae M
Abstract excerpt
Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system (CNS). Excitatory amino acid transporters (EAATs) regulate extracellular glutamate by transporting it into cells, mostly glia, to terminate neurotransmission and to avoid neurotoxicity. EAATs are also chloride (Cl-) channels, but the physiological role of Cl- conductance through EAATs is poorly understood. Mutations...
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