Article
A carcinogenesis model describing mutational events at the DNA adduct level.
Mathematical biosciences - 1 Aug 1997
Zheng O, Lutz W K, Gaylor D W
Abstract excerpt
A stochastic carcinogenesis model is proposed to describe a sequence of component mutational changes that constitute the G:C-->A:T base substitution. This paper provides the biological basis and mathematical formulation underlying the proposed model. In addition, the paper elaborates on a numerical approach for studying the cumulant functions, survival functions, and hazard functions of the model. Several...
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