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Aflatoxin B1 Alters the Expression of p53 in Cytochrome P450-Expressing Human Lung Cells

9 Nov 2005

Abstract excerpt

Aflatoxin B1 (AFB1) is a potent dietary hepatocarcinogen in animals and probably in humans. Mutations (and altered expression) of the tumor suppresser gene p53 have been observed in liver tumors from patients exposed to high dietary AFB1. Inhalation of AFB1-laden grain dusts has been associated with an increased incidence of lung cancer in humans as well. We examined the effects of low concentrations of AFB1 on...

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PMID: 16280384
DOI: 10.1093/toxsci/kfj039

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