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Article

Cellular interactions and metabolism of aflatoxin: an update.

Pharmacology & therapeutics - 1 Feb 1995

McLean M, Dutton M F

Abstract excerpt

The aflatoxins are a group of closely related mycotoxins that are widely distributed in nature. The most important of the group is aflatoxin B1 (AFB1), which has a range of biological activities, including acute toxicity, teratogenicity, mutagenicity and carcinogenicity. In order for AFB1 to exert its effects, it must be converted to its reactive epoxide by the action of the mixed function mono-oxygenase enzyme...

Topics

Abnormalities, Drug-Induced
Aflatoxin B1
Aflatoxins
Animals
Carcinogens
Carcinoma, Hepatocellular
Cytochrome P-450 Enzyme System
DNA
Humans
Liver Neoplasms
Mutation
Mycotoxicosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proteins

RNA

Structure-Activity Relationship

Source

Identifiers

PMID: 7540767
DOI: 10.1016/0163-7258(94)00054-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7540767-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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