Article
Development of resistance of human immunodeficiency virus type 1 to dextran sulfate associated with the emergence of specific mutations in the envelope gp120 glycoprotein.
Molecular pharmacology - 1 Jul 1997
Este J A, Schols D, De Vreese K, Van Laethem K, Vandamme A M, Desmyter J, De Clercq E
Abstract excerpt
Polyanionic compounds are known to inhibit the binding of human immunodeficiency virus (HIV) to CD4+ cells and the subsequent fusion step between the virus and cells. We selected an HIV-1 strain resistant to dextran sulfate (DS) by cultivation of HIV-1 (NL4-3)-infected MT-4 cells in the presence of DS Mr 5000. DS did not inhibit the binding of DS-resistant virus to MT-4 cells or syncytium formation between MOLT...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.