Article
FP-21399 blocks HIV envelope protein-mediated membrane fusion and concentrates in lymph nodes.
Nature biotechnology - 1 Apr 1997
Ono M, Wada Y, Wu Y, Nemori R, Jinbo Y, Wang H, Lo K M, Yamaguchi N, Brunkhorst B, Otomo H, Wesolowski J, Way J C, Itoh I, Gillies S, Chen L B
Abstract excerpt
The identification of fusin and other chemokine receptors as coreceptors for HIV-1 has renewed the interest in agents that may prevent viral entry. Polyanionic compounds such as dextran sulfate, curdian sulfate, and suramin act on the V3 loop of the viral envelope and may prevent its interaction with fusin. These agents show activity against a wide range of HIV-1 strains, but have undesirable circulating...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.