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Article

The anti-HIV activity of ADS-J1 targets the HIV-1 gp120.

Virology - 5 Dec 2005

Armand-Ugón Mercedes, Clotet-Codina Imma, Tintori Cristina, Manetti Fabrizio, Clotet Bonaventura, Botta Maurizio, Esté José A

Abstract excerpt

Recent data suggest that heparin sulfates may bind to a CD4 induced epitope in the HIV-1 gp120 that constitutes the coreceptor binding site. We have studied the mechanism of action of ADS-J1, a non-peptidic compound selected by docking analysis to interact with gp41 and to interfere with the formation of N-36/C-34 complexes in sandwich ELISA experiments. We show that ADS-J1 blocked the binding of wild-type HIV-1...

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Identifiers

PMID: 16168454
DOI: 10.1016/j.virol.2005.08.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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