Article
HIV-1 resistance to the gp41-dependent fusion inhibitor C-34.
Antiviral research - 1 Jul 2003
Armand-Ugón Mercedes, Gutiérrez Arantxa, Clotet Bonaventura, Esté José A
Abstract excerpt
The gp41 subunit of HIV-1 has been recently recognized as a target for antiviral therapy. C-34 is a peptide that mimics the heptad repeat 2 in the ectodomain of gp41. Here, we describe two HIV-1 strains selected after 5 and 17 passages in culture with increasing concentrations of C-34 (breakthrou...
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