Article
Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology.
Antiviral chemistry & chemotherapy - 1 Jan 2005
Hantson Anke, Fikkert Valery, Van Remoortel Barbara, Pannecouque Chistophe, Cherepanov Peter, Matthews Barry, Holan George, De Clercq Erik, Vandamme Anne-Mieke, Debyser Zeger, Witvrouw Myriam
Abstract excerpt
A drug-resistant NL4.3/SPL2923 strain has previously been generated by in vitro selection of HIV-1(NL4.3) in the presence of the polysulfonic dendrimer SPL2923 and mutations were reported in its gp120 gene (Witvrouw et al., 2000). Here, we further analysed the (cross) resistance profile of NL4.3/SPL2923. NL4.3/SPL2923 was found to contain additional mutations in gp41 and showed reduced susceptibility to SPL2923,...
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