Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells.

Cancer research - 1 May 2004

Psyrri Amanda, DeFilippis Rosa Anna, Edwards Anne P B, Yates Kristin E, Manuelidis Laertes, DiMaio Daniel

Abstract excerpt

Repression of the endogenous human papillomavirus (HPV) type 18 E7 gene in HeLa cervical carcinoma cells by the bovine papillomavirus E2 transcription factor activates the retinoblastoma (Rb) pathway and induces cells to undergo senescence. To determine whether activation of the Rb pathway is responsible for senescence in response to HPV18 E7 repression, we tested the ability of wild-type and mutant E7 proteins...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenovirus E1A Proteins
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Oncogene Proteins, Viral

Share to Papillomaviridae

Share to Papillomavirus E7 Proteins

Share to Retinoblastoma Protein

Share to Uterine Cervical Neoplasms

Source

Identifiers

PMID: 15126344
DOI: 10.1158/0008-5472.can-03-3739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells.PMID 15126344Read ↗

Human Papillomavirus E7 Repression in Cervical Carcinoma Cells Initiates a Transcriptional Cascade Driven by the Retinoblastoma Family, Resulting in SenescenceSemantic proximity Read ↗

Endogenous Human Papillomavirus E6 and E7 Proteins Differentially Regulate Proliferation, Senescence, and Apoptosis in HeLa Cervical Carcinoma CellsSemantic proximity Read ↗

Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells.Semantic proximity Read ↗

Rapid induction of senescence in human cervical carcinoma cellsSemantic proximity Read ↗

Transition to an irreversible state of senescence in HeLa cells arrested by repression of HPV E6 and E7 genes.Semantic proximity Read ↗

CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cellsSemantic proximity Read ↗

Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathwaysSemantic proximity Read ↗

CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 and E7 induces senescence in cervical cancer cellsSemantic proximity Read ↗

Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways.Semantic proximity Read ↗

Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory geneSemantic proximity Read ↗

Inactivation of both the Retinoblastoma Tumor Suppressor and p21 by the Human Papillomavirus Type 16 E7 Oncoprotein Is Necessary To Inhibit Cell Cycle Arrest in Human Epithelial CellsSemantic proximity Read ↗

Tumor suppressor p16 <sup>INK4A</sup> is necessary for survival of cervical carcinoma cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.