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Article

HPV-18 E6 mutants reveal p53 modulation of viral DNA amplification in organotypic cultures.

Proceedings of the National Academy of Sciences of the United States of America - 7 May 2013

Kho Eun-Young, Wang Hsu-Kun, Banerjee N Sanjib, Broker Thomas R, Chow Louise T

Abstract excerpt

Human papillomaviruses (HPVs) amplify in differentiated strata of a squamous epithelium. The HPV E7 protein destabilizes the p130/retinoblastoma susceptibility protein family of tumor suppressors and reactivates S-phase reentry, thereby facilitating viral DNA amplification. The high-risk HPV E6 protein destabilizes the p53 tumor suppressor and many other host proteins. However, the critical E6 targets relevant to...

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Share to Genes, p53
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Complementation Test

Share to Human papillomavirus 18

Share to Integrases

Share to Keratinocytes

Share to Oncogene Proteins, Viral

Share to RNA, Small Interfering

Source

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Identifiers

PMID: 23572574
DOI: 10.1073/pnas.1304855110
PMCID: PMC3651465

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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