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Article

Examination of the pRb-Dependent and pRb-Independent Functions of E7 In Vivo

15 Aug 2005

Abstract excerpt

High-risk human papillomaviruses encode two oncogenes, E6 and E7, expressed in nearly all cervical cancers. Although E7 protein is best known for its ability to inactivate the retinoblastoma tumor suppressor protein, pRb, many other activities for E7 have been proposed in in vitro studies. Herein, we describe studies that allowed us to define unambiguously the pRb-dependent and -independent activities of E7 for...

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PMID: 16103190
DOI: 10.1128/jvi.79.17.11392-11402.2005

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