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Article

Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1991

Michelsen B K, Petersen J S, Boel E, Møldrup A, Dyrberg T, Madsen O D

Abstract excerpt

A 64-kDa islet protein is a major autoantigen in insulin-dependent diabetes mellitus (IDDM). Autoantibodies against the 64-kDa protein were recently shown to immunoprecipitate glutamic acid decarboxylase (GAD; L-glutamate 1-carboxy-lyase, EC 4.1.1.15) from brain and from islets. We present evidence that the autoantisera also recognize a hydrophilic islet protein of approximately 67 kDa in addition to the...

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Identifiers

PMID: 1924335
DOI: 10.1073/pnas.88.19.8754
PMCID: PMC52588

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus.PMID 1924335Read ↗

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