Article
Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1991
Michelsen B K, Petersen J S, Boel E, Møldrup A, Dyrberg T, Madsen O D
Abstract excerpt
A 64-kDa islet protein is a major autoantigen in insulin-dependent diabetes mellitus (IDDM). Autoantibodies against the 64-kDa protein were recently shown to immunoprecipitate glutamic acid decarboxylase (GAD; L-glutamate 1-carboxy-lyase, EC 4.1.1.15) from brain and from islets. We present eviden...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Autoantigens
- Cloning, Molecular
- Diabetes Mellitus, Type 1
- Glutamate Decarboxylase
- Humans
- Insulinoma
- Islets of Langerhans
- Molecular Sequence Data
- Molecular Weight
- Precipitin Tests
- RNA Splicing
- RNA, Messenger