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Article

The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Dec 2008

Zuberi Zia, Birnbaumer Lutz, Tinker Andrew

Abstract excerpt

Multiple isoforms of inhibitory Galpha-subunits (Galphai1,2,3, as well as Galphao) are present within the heart, and their role in modulating pacemaker function remains unresolved. Do inhibitory Galpha-subunits selectively modulate parasympathetic heart rate responses? Published findings using a variety of experimental approaches have implicated roles for Galphai2, Galphai3, and Galphao in parasympathetic signal...

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Identifiers

PMID: 18832081
DOI: 10.1152/ajpregu.90625.2008
PMCID: PMC3395347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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