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Article

Activated mutant of Galpha(12) enhances the hyperosmotic stress response of NIH3T3 cells.

Journal of cellular biochemistry - 1 Jan 2001

Dermott J M, Wadsworth S J, van Rossum G D, Dhanasekaran N

Abstract excerpt

Heterotrimeric G protein G12 stimulates diverse physiological responses including the activities of Na+/H+ exchangers and Jun kinases. We have observed that the expression of the constitutively activated, GTPase-deficient mutant of Galpha(12) (Galpha(12)QL) accelerates the hyperosmotic response of NIH3T3 cells as monitored by the hyperosmotic stress-stimulated activity of JNK1. The accelerated response appears to...

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PMID: 11180393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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