Article
Role of CFTR in lysosome acidification.
Biochemical and biophysical research communications - 15 Apr 1992
Van Dyke R W, Root K V, Schreiber J H, Wilson J M
Abstract excerpt
The role of CFTR in lysosome acidification was examined in CFPAC-1 pancreatic adenocarcinoma cells with the delta F508 mutation that were transduced with a retroviral vector (PLJ-CFPAC) or with the normal CFTR gene (CFTR-CFPAC). Steady-state lysosomal pHi in intact cells was lower in PLJ-CFPAC ce...
Topics
- Adenocarcinoma
- Adenosine Triphosphate
- Bucladesine
- Carbonyl Cyanide m-Chlorophenyl Hydrazone
- Cell Line
- Colforsin
- Cyclic AMP
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Dextrans
- Fluorescein-5-isothiocyanate
- Fluorescent Dyes
- Hydrogen-Ion Concentration
- Kinetics
- Lysosomes
- Membrane Proteins
- Monensin
- Mutation