Article
Role of CFTR in lysosome acidification.
Biochemical and biophysical research communications - 15 Apr 1992
Van Dyke R W, Root K V, Schreiber J H, Wilson J M
Abstract excerpt
The role of CFTR in lysosome acidification was examined in CFPAC-1 pancreatic adenocarcinoma cells with the delta F508 mutation that were transduced with a retroviral vector (PLJ-CFPAC) or with the normal CFTR gene (CFTR-CFPAC). Steady-state lysosomal pHi in intact cells was lower in PLJ-CFPAC cells than CFTR-CFPAC cells (3.55 vs 3.80) and was not affected by cAMP or forskolin. Initial rates of ATP-dependent...
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