Article
Monogenetic determinants of Alzheimer's disease: APP mutations.
Cellular and molecular life sciences : CMLS - 1 Sept 1998
Goate A M
Abstract excerpt
Mutations within exons 16 and 17 of the beta-amyloid precursor protein (APP) gene were the first known cause of familial Alzheimer's disease. These mutations are rare and have been reported in a handful of families exhibiting autosomal dominant inheritance of Alzheimer's disease with age of onset...
Topics
- Age of Onset
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Apolipoproteins E
- Brain
- Cerebral Hemorrhage
- Disease Models, Animal
- Exons
- Genes, Dominant
- Humans
- In Vitro Techniques
- Mice
- Mice, Knockout
- Mice, Transgenic
- Middle Aged
- Mutation
- Phenotype