Article
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.
Science (New York, N.Y.) - 18 Jul 1997
Scheffzek K, Ahmadian M R, Kabsch W, Wiesmüller L, Lautwein A, Schmitz F, Wittinghofer A
Abstract excerpt
The three-dimensional structure of the complex between human H-Ras bound to guanosine diphosphate and the guanosine triphosphatase (GTPase)-activating domain of the human GTPase-activating protein p120GAP (GAP-334) in the presence of aluminum fluoride was solved at a resolution of 2.5 angstroms....
Topics
- Aluminum Compounds
- Amino Acid Sequence
- Binding Sites
- Catalysis
- Cell Transformation, Neoplastic
- Crystallography, X-Ray
- Enzyme Activation
- Fluorides
- GTP Phosphohydrolases
- GTP-Binding Proteins
- GTPase-Activating Proteins
- Guanosine Diphosphate
- Guanosine Triphosphate
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation