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Article

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.

Science (New York, N.Y.) - 18 Jul 1997

Scheffzek K, Ahmadian M R, Kabsch W, Wiesmüller L, Lautwein A, Schmitz F, Wittinghofer A

Abstract excerpt

The three-dimensional structure of the complex between human H-Ras bound to guanosine diphosphate and the guanosine triphosphatase (GTPase)-activating domain of the human GTPase-activating protein p120GAP (GAP-334) in the presence of aluminum fluoride was solved at a resolution of 2.5 angstroms. The structure shows the partly hydrophilic and partly hydrophobic nature of the communication between the two...

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PMID: 9219684
DOI: 10.1126/science.277.5324.333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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