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Article

Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf.

Structure (London, England : 1993) - 1 Dec 2007

Buhrman Greg, Wink Glenna, Mattos Carla

Abstract excerpt

Transformation efficiencies of Ras mutants at residue 61 range over three orders of magnitude, but the in vitro GTPase activity decreases 10-fold for all mutants. We show that Raf impairs the GTPase activity of RasQ61L, suggesting that the Ras/Raf complex differentially modulates transformation. Our crystal structures show that, in transforming mutants, switch II takes part in a network of hydrophobic...

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Identifiers

PMID: 18073111
DOI: 10.1016/j.str.2007.10.011
PMCID: PMC2273997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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