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Article

Why does the Ras switch "break" by oncogenic mutations?

Proteins - 1 Apr 2004

Shurki Avital, Warshel Arieh

Abstract excerpt

The elucidation of the structure of the RasGAP complex provides what is perhaps the most detailed link between protein structure and cancer causing mutations. In particular, it is known that mutations of Gln 61 destroy the GTPase activity of the complex, locks the cell in its ON state and thus, can cause cancer. It is entirely unclear however, why this specific mutation is so important. The present work uncovers...

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Identifiers

PMID: 14997535
DOI: 10.1002/prot.20004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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