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Article

Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction.

Biological chemistry - 1 Sept 2008

Gremer Lothar, Gilsbach Bernd, Ahmadian Mohammad Reza, Wittinghofer Alfred

Abstract excerpt

Down-regulation of Ras signalling is mediated by specific GTPase-activating proteins (GAPs), which stimulate the very slow GTPase reaction of Ras by 10(5)-fold. The basic features of the GAP activity involve the stabilisation of both switch regions of Ras in the transition state, and the insertion of an arginine finger. In the case of oncogenic Ras mutations, the features of the active site are disturbed. To...

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Identifiers

PMID: 18713003
DOI: 10.1515/BC.2008.132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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