Thymic T-cell lymphoma with the CD8+ (OX-8), CD4+ (W3/25) phenotype, induced in F344/NCr rats by nitroso-2-hydroxypropylurea.

Article

Thymic T-cell lymphoma with the CD8+ (OX-8), CD4+ (W3/25) phenotype, induced in F344/NCr rats by nitroso-2-hydroxypropylurea.

Thymus - 1 Jan 2000

Konishi N, Ward J M, Reynolds C W, Lijinsky W

Abstract excerpt

Thymic T-cell lymphomas were induced by administration of nitroso-2-hydroxypropylurea (NHPU) at a dose of 1.6 mg by gavage twice weekly for each of 20 weeks in F344/NCr rats. Lymphomas began to appear 5-10 weeks after the first intubation. Primary and transplantable tumors were subjected to morph...

Topics

Animals
Lymphoma
Male
Neoplasm Transplantation
Nitroso Compounds
Phenotype
Rats
Rats, Inbred F344
T-Lymphocytes
Thymus Neoplasms

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