Article
Deciphering the role of individual acyl chains in the interaction network between phosphatidylserines and a single-spanning membrane protein.
Biochemistry - 19 Nov 2002
Mousson Florence, Coïc Yves-Marie, Baleux Françoise, Beswick Veronica, Sanson Alain, Neumann Jean-Michel
Abstract excerpt
PMP1 is a small single-spanning membrane protein functioning as a regulatory subunit of the yeast plasma membrane H(+)-ATPase. This protein forms a unique helix and exhibits a positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines (PSs). A marked groove formed at the helix surface is thought to play a major role in the related lipid-protein interaction network. Mutational...
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