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Article

Characterization of yeast plasma membrane H(+)-ATPase mutant pma1-A135V and its revertants.

The Journal of biological chemistry - 5 Jun 1993

Na S, Perlin D S, Seto-Young D, Wang G, Haber J E

Abstract excerpt

An A135V substitution in the first transmembrane segment of the yeast plasma membrane H(+)-ATPase (PMA1) confers cellular resistance to hygromycin B, exhibits growth sensitivity to low external pH, and results in a defective enzyme that hydrolyzes ATP at 33% of wild type level. The importance of the A135 residue was probed genetically by analysis involving both site-directed mutagenesis and randomly generated...

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PMID: 8505307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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