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Article

Rules for RNA recognition of GNRA tetraloops deduced by in vitro selection: comparison with in vivo evolution.

The EMBO journal - 2 Jun 1997

Costa M, Michel F

Abstract excerpt

Terminal loops with a GNRA consensus sequence are a prominent feature of large self-assembling RNA molecules. In order to investigate tertiary interactions involving GNRA loops, we have devised an in vitro selection system derived from a group I ribozyme. Two selections, destined to isolate RNA sequences that would recognize two of the most widespread loops (GUGA and GAAA), yielded variants of previously...

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Identifiers

PMID: 9214644
DOI: 10.1093/emboj/16.11.3289
PMCID: PMC1169945

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Source receipt: pubmed, retrieved 7 Sept 2026.

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