Rules for RNA recognition of GNRA tetraloops deduced by in vitro selection: comparison with in vivo evolution.

doi:10.1093/emboj/16.11.3289

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Article

Rules for RNA recognition of GNRA tetraloops deduced by in vitro selection: comparison with in vivo evolution.

The EMBO journal - 2 Jun 1997

Costa M, Michel F

Abstract excerpt

Terminal loops with a GNRA consensus sequence are a prominent feature of large self-assembling RNA molecules. In order to investigate tertiary interactions involving GNRA loops, we have devised an in vitro selection system derived from a group I ribozyme. Two selections, destined to isolate RNA s...

Topics

Binding Sites
Consensus Sequence
Evolution, Molecular
Genetic Variation
Kinetics
Models, Molecular
Nucleic Acid Conformation
RNA, Catalytic
Selection, Genetic
Sequence Homology, Nucleic Acid
Substrate Specificity

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