Article
In vitro selection of a viomycin-binding RNA pseudoknot.
Chemistry & biology - 1 May 1997
Wallis M G, Streicher B, Wank H, von Ahsen U, Clodi E, Wallace S T, Famulok M, Schroeder R
Abstract excerpt
BACKGROUND: The peptide antibiotic viomycin inhibits ribosomal protein synthesis, group I intron self-splicing and self-cleavage of the human hepatitis delta virus ribozyme. To understand the molecular basis of RNA binding and recognition by viomycin, we isolated a variety of novel viomycin-binding RNA molecules using in vitro selection. RESULTS: More than 90% of the selected RNA molecules shared one continuous...
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