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Article

A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.

Science (New York, N.Y.) - 24 Feb 1995

Szankasi P, Smith G R

Abstract excerpt

Exonuclease I (Exo I) from Schizosaccharomyces pombe, a 5'-->3' double-stranded DNA exonuclease, is induced during meiotic prophase I. The exo1 gene is a member of a family of related DNA repair genes, including RAD2/rad13/xpgc and YKL510/rad2, conserved from yeast to humans. An exo1 mutant displays a mutator phenotype and alters activity of the ade6-M387 marker effect. These results suggest that Exo I acts in a...

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PMID: 7855597
DOI: 10.1126/science.7855597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Click a neighbor to travelStep 1 · 12 closest

A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction.PMID 7855597Read ↗

Requirement of S. pombe exonuclease II, a homologue of S. cerevisiae Sep1, for normal mitotic growth and viability.Semantic proximity Read ↗

Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance.Semantic proximity Read ↗

EXO1-A multi-tasking eukaryotic nuclease.Semantic proximity Read ↗

Exonuclease 1-dependent and independent mismatch repair.Semantic proximity Read ↗

Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae.Semantic proximity Read ↗

Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability.Semantic proximity Read ↗

The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification and characterization of <i>Saccharomyces cerevisiae EXO1</i> , a gene encoding an exonuclease that interacts with MSH2Semantic proximity Read ↗

Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in CancerSemantic proximity Read ↗

Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility.Semantic proximity Read ↗

A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.Semantic proximity Read ↗

Mismatch repair in Schizosaccharomyces pombe requires the mutL homologous gene pms1: molecular cloning and functional analysis.Semantic proximity Read ↗

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