Article
[Mutagenic effect of nitrosodimethylurea in male mice. Induction of dominant lethal mutations and chromosome aberrations in germ cells; genotype influence on the clastogenic effect in bone marrow cells].
Genetika - 1 Apr 1997
Malashenko A M, Beskova T B, Vasil'eva S V
Abstract excerpt
The ability of dimethylnitrosourea (DMNU) to induce dominant lethal mutations in germ cells and chromosome aberrations in bone marrow cells of male CBAB6F1 mice was studied. At a mutagen dose of 200 mg/kg, mortality was 19% in the second week after treatment (being 5% in the control) and the freq...
Topics
- Animals
- Bone Marrow
- Chromosome Aberrations
- Genes, Dominant
- Genes, Lethal
- Genotype
- Male
- Methylnitrosourea
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mutagenicity Tests
- Mutagens
- Spermatogonia
- Spermatozoa