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Article

[In vivo micronuclei and gene mutation induced by DEN in the lacZ transgenic mouse].

Wei sheng yan jiu = Journal of hygiene research - 1 May 2005

Zhan Li, Zhang Li-Shi, Wang Li, Zhu Ling, Zhang Hao, Suzuki Takamasa, Wu Desheng

Abstract excerpt

OBJECTIVE: To assess mutagenicity of N-nitrosodiethylamine (DEN) in vivo using the lacZ transgenic mouse (Muta Mouse). METHODS: LacZ gene was recovered through in vitro packing. Mutant frequencies (MFs) in the lacZ gene of liver, lung and bladder were examined after intraperitoneal treatment with DEN (25mg/kg per week x 4). Simultaneously, the clastogenicity of DEN was evaluated by the peripheral blood...

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PMID: 16111025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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