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[1,4-dihydroisonicotinic acid (1,4-DHINA) derivatives, inhibitors of chemical mutagenesis].

Vestnik Rossiiskoi akademii meditsinskikh nauk - 1 Jan 1995

Goncharova R I, Kuzhir T D, Dalivelia O V, Dubur G Ia, Uldrikis Ia R

Abstract excerpt

The paper summarizes the results of studies into the modifying effect of some 1,4-dihydroisonicotinic acid (1,4-DHINA) derivatives during chemical mutagenesis in eukaryotic organisms. The compounds under study are effective in reducing the incidence of point and chromosomal mutations induced by ethylmethane sulfonate (EMS) in Drosophila sex cells, displaying the specificity of the influence depending on some...

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PMID: 7767123

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