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Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase

1 Oct 2000

Abstract excerpt

O(6)-methylguanine-DNA methyltransferase plays vital roles in preventing induction of mutations and cancer as well as cell death related to alkylating agents. Mice defective in the MGMT: gene, encoding the methyltransferase, were used to evaluate cell death-inducing and tumorigenic activities of therapeutic agents which have alkylation potential. MGMT(-/-) mice were considerably more sensitive to dacarbazine, a...

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PMID: 11023546
DOI: 10.1093/carcin/21.10.1879

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