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Article

Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model.

The Journal of cell biology - 21 Nov 2005

Xian Wa, Schwertfeger Kathryn L, Vargo-Gogola Tracy, Rosen Jeffrey M

Abstract excerpt

Members of the fibroblast growth factor (FGF) family and the FGF receptors (FGFRs) have been implicated in mediating various aspects of mammary gland development and transformation. To elucidate the molecular mechanisms of FGFR1 action in a context that mimics polarized epithelial cells, we have developed an in vitro three-dimensional HC11 mouse mammary epithelial cell culture model expressing a drug-inducible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Imaging, Three-Dimensional

Share to Mammary Glands, Animal

Share to Matrix Metalloproteinase 3

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Share to Receptor, Fibroblast Growth Factor, Type 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 16301332
DOI: 10.1083/jcb.200505098
PMCID: PMC2171554

Genes

FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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