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Fgf10/Fgfr2b Signaling in Mammary Gland Development, Homeostasis, and Cancer

26 Jun 2020

Abstract excerpt

Fibroblast growth factor 10 (Fgf10) is a secreted ligand acting via the Fibroblast growth factor receptor 2b (Fgfr2b). Fgf10/Fgfr2b signaling plays important roles both in the epithelium and in the mesenchyme during mammary gland development. Evidence in mice show that Fgf10 is critical for the induction of four out of five of the mammary placodes and for the formation of the white adipose tissue. Fgfr2b ligands...

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PMID: 32676501
DOI: 10.3389/fcell.2020.00415

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