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Article

Targeted expression of the dominant-negative prolactin receptor in the mammary gland of transgenic mice results in impaired lactation.

Endocrinology - 1 Jun 2003

Saunier Elise, Dif Fariel, Kelly Paul A, Edery Marc

Abstract excerpt

The F3-short form of the rat PRL receptor (F3-SPRLR) form acts as a dominant negative inhibitor in vitro. We have developed a transgenic mouse model in which the rat F3-SPRLR was expressed in mammary epithelium under the control of the mouse mammary tumor virus promoter. Two lines of mice were characterized and shown to express the transgene in the mammary gland. No developmental abnormalities or differences from...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12746331
DOI: 10.1210/en.2002-221038

Genes

PRL
PRLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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