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Article

Human breast cancer growth inhibited in vivo by a dominant negative pleiotrophin mutant.

The Journal of biological chemistry - 4 Jul 1997

Zhang N, Zhong R, Wang Z Y, Deuel T F

Abstract excerpt

Pleiotrophin (PTN) is a recently described 18- kDa heparin binding growth/differentiation factor. It also is a proto-oncogene; cells transformed by the Ptn gene form highly angiogenic tumors when implanted into the nude mouse. PTN may be an important regulator of transformation in other tumors, b...

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Source

Identifiers

PMID: 9201975
DOI: 10.1074/jbc.272.27.16733

Genes

PTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9201975-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Human breast cancer growth inhibited in vivo by a dominant negative pleiotrophin mutant.PMID 9201975Read ↗

Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer.Semantic proximity Read ↗

Dominant negative pleiotrophin induces tetraploidy and aneuploidy in U87MG human glioblastoma cells.Semantic proximity Read ↗

Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin–binding growth and differentiation factorsSemantic proximity Read ↗

A dominant-negative pleiotrophin mutant introduced by homologous recombination leads to germ-cell apoptosis in male mice.Semantic proximity Read ↗

Development of an Autocrine Neuregulin Signaling Loop with Malignant Transformation of Human Breast Epithelial CellsSemantic proximity Read ↗

Pleiotrophin induces formation of functional neovasculature in vivo.Semantic proximity Read ↗

Pleiotrophin expression and role in physiological angiogenesis in vivo: potential involvement of nucleolinSemantic proximity Read ↗

[A pleiotrophin-specific siRNA and its effect on PTEN-/- MEF241 cells].Semantic proximity Read ↗

Osteopontin is required for full expression of the transformed phenotype by the ras oncogene.Semantic proximity Read ↗

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