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Article

A dominant-negative pleiotrophin mutant introduced by homologous recombination leads to germ-cell apoptosis in male mice.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 1999

Zhang N, Yeh H J, Zhong R, Li Y S, Deuel T F

Abstract excerpt

Pleiotrophin (PTN) is an 18-kDa heparin-binding secretory growth/differentiation factor for different cell types. Its gene is differentially expressed in both mesenchyme and central nervous system during development and highly expressed in a number of different human tumors. Recently, a PTN mutant was found to act as a dominant-negative effector of PTN signaling. We have now used homologous recombination to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Genes, Dominant

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Share to Recombination, Genetic

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Source

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Identifiers

PMID: 10359781
DOI: 10.1073/pnas.96.12.6734
PMCID: PMC21984

Genes

PTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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