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Article

Dominant negative pleiotrophin induces tetraploidy and aneuploidy in U87MG human glioblastoma cells.

Biochemical and biophysical research communications - 15 Dec 2006

Chang Yunchao, Berenson James R, Wang Zhaoyi, Deuel Thomas F

Abstract excerpt

Pleiotrophin (PTN, Ptn) is an 18kDa secretory cytokine that is expressed in many human cancers, including glioblastoma. In previous experiments, interruption of the constitutive PTN signaling in human U87MG glioblastoma cells that inappropriately express endogenous Ptn reversed their rapid growth...

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Identifiers

PMID: 17067552
DOI: 10.1016/j.bbrc.2006.09.148
PMCID: PMC1850963

Genes

PTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17067552-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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