Article
[V gene repertoire and pathogenic autoantibodies].
Nihon rinsho. Japanese journal of clinical medicine - 1 Jun 1997
Hirabayashi Y, Munakata Y, Saitou S, Sasaki T
Abstract excerpt
The studies for autoantibody-associated V genes have failed to find any V gene which might be specific for pathogenic autoantibodies in humans; Namely, both normal subjects and patients have immunoglobulin V genes which can encode autoantibodies. Also single V gene can encode antibodies for both...
Topics
- Animals
- Antibodies, Antinuclear
- Autoimmune Diseases
- B-Lymphocytes
- Clonal Deletion
- Gene Rearrangement
- Genes, Immunoglobulin
- Haplotypes
- Humans
- Lupus Erythematosus, Systemic
- Mutation