[Immunoglobulin variable region gene rearrangement and hypermutation in paraneoplastic pemphigus associated Castleman's tumor].

Abstract excerpt

OBJECTIVE: We have studied the role of lymphoproliferative tumors in the pathogenesis of autoimmune and the origin of the autoantibodies in paraneoplastic pemphigus (PNP) in recent years. A Castleman's tumor from a patient was identified to produce autoantibody. To identify the relationship between the tumor and pathogenesis of the disease, we analyzed the rearrangement of immunoglobulin variable region gene and...

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