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Article

Determinants of T cell reactivity to the Mycobacterium leprae GroES homologue.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1997

Kim J, Sette A, Rodda S, Southwood S, Sieling P A, Mehra V, Ohmen J D, Oliveros J, Appella E, Higashimoto Y, Rea T H, Bloom B R, Modlin R L

Abstract excerpt

The 10-kDa protein Ag of Mycobacterium leprae, a human GroES hsp10 cognate, is a major T cell Ag in human leprosy infection. We investigated the mechanism for T cell responsiveness to this Ag according to the trimolecular interaction between T cell, peptide, and Ag-presenting element. This research was accomplished by mapping T cell epitopes in leprosy patients and correlating these responses with peptide-MHC...

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PMID: 9200471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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